However this process is done selectively in few patients who show consistently thin endometrium or recurrent implantation failure. Many studies report that there may be improvement in embryo implantation rate if an endometrial scratching is done prior to Embryo Transfer in an IVF cycle. Does endometrial scratching improve implantation rate of Embryo after Embryo Transfer ? The process of scratching the lining of the uterus is called endometrial scratching.Įndometrial biopsy involves scratching the endometrium and then removing the tissue so that the tissue can be studied by a laboratory for presence of absence of infection etc. Is endometrial biopsy same as endometrial scratching ? Many studies suggest that endometrial scratching can actually improve the embryo implantation rate if done before embryo transfer. What is the difference between endometrial biopsy procedure and endometrial scratching ?Įndometrial biopsies are taken by a process of scratching the endometrium and removing the small tissue which is then sent to the laboratory for studying the cells under microscope. There are no side effects of the endometrial biopsy procedure if done by experienced doctor. What are the side effects of Endometrial Biopsy or TBPCR procedure ? PCR report if sent comes back positive indicating presence of infection Microscopic Examination reveals evidence of infection or inflammation Presence of overgrowth of the lining of the uterus (endometrial hyperplasia).įor women who have menstrual cycles, the lining of the uterus is NOT at the right stage for the time in the menstrual cycle Presence of a non cancerous (benign) growth, called a polyp. The lining of the uterus is at the right stage for time in the menstrual cycle on Histopathology When the endometrial biopsy report does not show any evidence of infection/inflammation when seen under microscope, we can conclude that the test report is Normal. What does the test result of endometrial biopsy indicate ? Studies involving large numbers of women who had the procedure performed during the cycles when they conceived showed no greater incidence of birth defects or miscarriage. However, a woman undergoing an endometrial biopsy does NOT need to worry about disturbing a pregnancy. The time frame between Days 24 and 26 of the cycle is too early to perform a pregnancy test. Since the test is done close to the menstrual cycle, most patients have a valid concern “ What if I am pregnant?”

Concerns that you may have after the endometrial biopsy ? This will subside spontaneously after a few minutes as soon as the canula is withdrawn. It takes about 60 seconds to collect the tissue from the lining of uterus, during these 60 seconds the patient may experience mild cramping. A narrow plastic instrument (catheter) is passed into the uterus to collect a small sample of tissue from the side wall of the uterus. This may cause a brief, slight cramping sensation. An instrument called Allie’s forceps may be used to stabilize the cervix. The IVF specialist begins by inserting a speculum into the vagina.

The procedure is usually tolerated well by patients and leads to minor discomfort.Ī pain killer such as ibuprofen/paracetamol is given half an hour before the procedure so that patients feel less pain during the endometrial biopsy. In a woman with a 28-day cycle, it is usually scheduled for Days 21 to 26.įrom start to finish the test takes about five minutes by an experienced IVF doctor. The endometrial biopsy is best performed prior to menstruation or periods. For this particular indication,endometrial biopsy has largely been replaced by the less invasive 3 D Colour Doppler and 4 D Ultrasonography which gives an equally accurate description of the functional ability of the endometrium and also confirms ovulation.

To confirm ovulation and to check whether the endometrium is suitable for implantation of the embryo or not.Nowadays routinely offered to patients with Unexplained Infertility or as a part of Hysterolaparoscopy. Presence of infections like genital tuberculosis as a cause of Infertility (Known as Endometrial biopsy for TB PCR).The endometrial biopsy is ordered by the IVF specialist during a fertility work-up for two main purposes: Why is endometrial biopsy performed by an IVF specialist ? The scrapped tissue is checked under microscope by a pathologist and further evaluated with laboratory techniques such as PCR if required. Endometrial Biopsy or TB-PCR as it is normally known by many is a procedure performed by an IVF Specialist on an out patient basis.ĭuring the Endometrial biopsy a biopsy canula is inserted by an IVF doctor into the uterus transvaginally and a small piece of endometrium is scraped out for from the lining of the womb.

Endo biopsy